Born in Loudun, Renaudot received a doctorate of medicine from the University of Montpellier in 1606. He returned to Loudon where he met Cardinal Richelieu and Père Joseph. In the 1610s, Richelieu became more powerful and Renaudot followed him to Paris. Renaudot, a Protestant, converted to Catholicism once in Paris, and in short order, became the physician of Louis XIII of France. He also did a great deal to treat the poor.
Upon the deaths of Louis and Richelieu, Renaudot lost his license to practice in Paris. Cardinal Mazarin made Renaudot the historiographer of Louis XIV.
Théophraste Renaudot came as an unexpected guest to Lady Marie de Gournay's dinner and interviewed Up-timer Josh Modi and Colette Dubois for the weekly Gazette du France. In which Renaudot was at a pleasure in finally meeting the latter from Grantville. Renaudot was particularly interested in interviewing Colette for being the author of the Crucibellus Manuscripts, but Colette emotionally had to call off the interview in which Renaudot sympathetically understands and decided to interview her at a later point when she is ready.
After Renaudot had left, Colette talked with Josh about Renaudot and his drive for social justice and long supporting position in helping the poor and the unfortunates. And as well his desire to hear about new and interesting things.