Francesco Barberini (23 September 1597 – 10 December 1679) was an Italian Catholic Cardinal. The nephew of Pope Urban VIII (reigned 1623-1644), he benefited immensely from the nepotism practiced by his uncle. He was given various roles within the Vatican administration but his personal cultural interests, particularly in literature and the arts, meant that he became a highly significant patron. His secretary was the antiquarian Cassiano dal Pozzo who was also a discerning patron of the arts. Francesco was the elder brother of Cardinal Antonio Barberini and Taddeo Barberini who became Prince of Palestrina.