She was one of the first female artists to paint historical and religious paintings, at a time when such heroic themes were considered beyond a woman's reach.
Artemisia attended Galileo's hearing at the Church of San Matteo in Rome, thus being among the witnesses of Michel Ducos' ultimately-failed assassination attempt of Pope Urban VIII. She, like many other artists, would later create a painting of the attempt to present to the pope. But instead of painting USE Marine Corps calvary member Andrew Lennox taking the shot for Pope Urban or Father Lawrence Mazzare defending Galileo, she focused on Frank Stone comforting his brother Gerry after the latter accidentally shot Marius Pontigrazzi.
A week after the trial, Artemisia was invited by Cardinal Antonio Barberini to dine with him and the newly created Cardinal-protector Mazzare.